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Sickle Cell Disease and Bleeding Disorders

Sickle cell disease (SCD) and hemophilia and some other blood disorders are severe, lifelong and presently incurable diseases. We are instituting new programs to study and better treat iron overload in multiply transfused patients, comprehensive management of cardiac and pulmonary disease in SCD and other initiatives to improve the transiton of care from adolescence to adulthood and overall quality of life of these patients. University of Florida is at the forefront of research in AAV (adeno-associated virus) vectors for gene therapy that aims to cure SCD and hemophilia while promising to cure other similar illnesses caused by single gene defects.

Key Players

Dr. Levette Dunbar – Generalized Pediatric Hematologist
Ann Dove, RN – Nurse Coordinator for Comprehensive Sickle Cell and Hemophilia Program


Dr. Richard Lottenberg – Outcomes Research
Dr. Arun Srivastava – Safe vectors for gene therapy for Sickle Cell Anemia and other blood disorders
Dr. Jörg Bungert – Developmental regulation of the human globin genes
Dr. Roland Herzog – Develop gene therapy for the X-linked bleeding disorder hemophilia