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UF Health University of Florida
Division of Hematology & Oncology Department of Pediatrics in the College of Medicine
Matthew Cascio

Matthew Cascio, DO

Assistant Professor

Department: MD-PEDS-HEMATOLOGY
Business Phone: (352) 273-9120
Business Email: mcascio@ufl.edu

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About Matthew Cascio

Matthew Cascio, DO, is an assistant professor in the division of hematology and oncology in the department of pediatrics in the University of Florida College of Medicine.

After he achieved his bachelor’s degree in sociology from the Ohio State University in Columbus, Ohio, Dr. Cascio graduated with his doctor of osteopathy degree from Nova Southeastern University College of Osteopathic Medicine in Fort Lauderdale, Florida. He then pursued his residency in pediatrics at Penn State University College of Medicine in Hershey, Pennsylvania. The following year, Dr. Cascio completed his fellowship in the division of pediatric hematology and oncology at UF Health Shands Children’s Hospital.

Dr. Cascio is board-certified in pediatrics by the American Board of Pediatrics. Throughout his academic career, he was involved with various associations, such as the American Academy of Pediatrics and the Children’s Oncology Group. He has also received numerous honors, like the Sarcoma Foundation of America Award and Douglas J. Barrett Fellow Research Award. Dr. Cascio has extensive experience in research, with his interests including brain tumors, immunotherapy and programmatic development.

Dr. Cascio currently serves as the Interim Clinical Director of Pediatric Neuro-Oncology, and he is passionate about childhood advocacy, mentorship and clinical research.

Teaching Profile

Courses Taught

  1. MDC7400 – Pediatric Clerkship

    College of Medicine

  2. MDC7401 – Senior Pediatric Clk

    College of Medicine

Board Certifications

  • Pediatrics
    American Board of Pediatrics

Clinical Profile

Specialties

  • Cancer
  • Hematology and Oncology
  • Pediatrics

Areas of Interest

  • Brain tumor – children
  • Neurofibromatosis 2
  • Neurofibromatosis-1
  • Tuberous Sclerosis

Research Profile

The research efforts of Dr. Cascio are supported by STOP Children’s Cancer.

Areas of Interest

  • Brain Tumors
  • Immunotherapy
  • Programmatic Development

Publications

Academic Articles

  1. CAR T Cell Locomotion in Solid Tumor Microenvironment.

    Journal
    Cells.
    Volume/Issue
    11(12)
    [DOI]
    10.3390/cells11121974.
    [PMID]
    35741103.
    41 citations PubMed Publisher’s Site

  2. Novel application of single-cell next-generation sequencing for determination of intratumoral heterogeneity of canine osteosarcoma cell lines.

    Journal
    Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.
    Volume/Issue
    33(2):261-278
    [DOI]
    10.1177/1040638720985242.
    [PMID]
    33446089.
    14 citations PubMed Publisher’s Site

  3. Canine osteosarcoma checkpoint expression correlates with metastasis and T-cell infiltrate.

    Journal
    Veterinary immunology and immunopathology.
    Volume/Issue
    232
    [DOI]
    10.1016/j.vetimm.2020.110169.
    [PMID]
    33387703.
    25 citations PubMed Publisher’s Site

  4. A Case Presentation: Rare Occurrence of an Adolescent Male Presenting With an ATRT and Simultaneous Low-grade Glioneuronal Tumor.

    Journal
    Journal of pediatric hematology/oncology.
    Volume/Issue
    39(8):e456-e459
    [DOI]
    10.1097/MPH.0000000000000871.
    [PMID]
    28731919.
    PubMed Publisher’s Site

Grants

  1. LOGGIC/FIREFLY-2: A Phase 3, Randomized, International Multicenter Trial of DAY101 Monotherapy Versus Standard of Care Chemotherapy in Patients with Pediatric Low-Grade Glioma Harboring an Activating RAF Alteration Requiring First-Line Systemic Therapy

    Active

    Role:
    Principal Investigator
    Funding:
    DAY ONE BIOPHARMACEUTICALS

  2. An Immunological Strategy to Osteosarcoma: Reconditioning the Immune System with Adoptive CAR-T Cells and Reversal of Regulatory Pathways.

    Role:
    Principal Investigator
    Funding:
    HYUNDAI HOPE ON WHEELS

  3. CART Cells for Sarcoma

    Role:
    Principal Investigator
    Funding:
    Sarcoma Foundation of America

Education

  1. Fellowship, Pediatric Hematology/Oncology

    University of Florida College of Medicine

  2. Residency, Pediatrics

    Penn State University College of Medicine

  3. Doctor of Osteopathy Degree

    Nova Southeastern University College of Osteopathic Medicine

  4. Bachelor’s Degree, Sociology

    The Ohio State University

Contact Details

Phones:
Business:
(352) 273-9120
Emails:
Business:
mcascio@ufl.edu
Addresses:
Business Mailing:
PO Box 100296
 GAINESVILLE FL 32610
Business Street:
1600 SW ARCHER RD
 GAINESVILLE FL 32610