David A Ostrov

David A Ostrov

Associate Professor

Department: MD-PATHOLOGY
Business Phone: (352) 273-8166

Publications

2019 Current Opinion in Endocrinology Diabetes and Obesity
2018 The journal of allergy and clinical immunology. In practice
2015 Bioorganic & Medicinal Chemistry Letters
2014 Bioorganic & Medicinal Chemistry
2011 Acta Crystallographica. Section F, Structural Biology and Crystallization Communications
2009 Biochemical and Biophysical Research Communications
2009 Clinical Orthodontics and Research
2008 Journal of Molecular Graphics & Modelling
2008 Acta Crystallographica. Section F, Structural Biology and Crystallization Communications

Grants

Oct 2019 ACTIVE
Molecular modeling of HLA-B*39:01 interactions with infliximab
TEN PEAKS · Principal Investigator
Apr 2019 ACTIVE
Mapping the T cell receptor/antigen complex and identifying the genetic-based treatment in Sjogrens syndrome
NATL INST OF HLTH NIDCR ·
Oct 2017 – Dec 2017
Molecular docking of small molecules to HLA molecules
IMMUNOMOLECULAR THERAPEUTICS · Principal Investigator
Aug 2017 ACTIVE
Identification of potent cross neutralizing Dengue antibodies using single-cell technology
NATL INST OF HLTH NIAID · Project Manager
Jul 2017 ACTIVE
Enhancement of Biomarkers for Type 1 Diabetes
BAYLOR UNIV COLLEGE OF MEDICINE · Principal Investigator
Mar 2017 – Mar 2020
Identification of potent neutralizing Zika virus antibodies using single-cell analysis technology
FL DEPT OF HLTH ·
Dec 2016 – Mar 2018
Testing Skin Sensitizers for Binding to HLA
UT-BATTELLE · Principal Investigator
Aug 2016 ACTIVE
Novel DNA damage response gene from genomic screening
NATL INST OF HLTH NIEHS ·
May 2015 – Nov 2018
Novel small molecules for alpha-1 antitrypsin deficiency
FL DEPT OF HLTH BIOMED RES PGM/J&E KING · Principal Investigator
Dec 2013 – Nov 2016
Targeting Histone Methylation for Triple-Negative Breast
FL DEPT OF HLTH BANKHEAD-COLEY CANCER RE · Project Manager
Jul 2013 – Jun 2017
The Structural and Functional Basis of HLA-associated Drug Hypersensitivity
NATL INST OF HLTH NIAID · Principal Investigator
Jul 2006 ACTIVE
21st Century Research & Economic Development Investment Program (REDIP)
STATE UNIV SYS OF FL BOARD OF GOVERNORS · Project Manager

Patents

Published January 2009
Opsin Stabilizing Compounds and Methods of Use
#US2009-0286808
Published January 2011
Developing Novel Male Contraceptives and Anti-germ Cell Tumor Chemotherapeutics Using Small Compounds Selectively Inhibiting ANT4
#US-2011-0230564-A1
Published October 2011
Novel V-ATPase-Directed Bone Anabolic Agents
#US-2012-0046246-A1
Published November 2011
Novel Small Molecules that Target FAK and IGF-1R Receptor Protein Interactions
#20120107323-A1
Published December 2011
Novel Small Molecule Drugs, Targeting the FAK and Mdm-2 Interaction, as an Effective Cancer Therapy Approach
#20120100227
Published April 2012
Method for Preventing Diabetes Targeting of Autoantigenic Trimolecular Complexes
#US 2012/0195929 A1
Issued November 2012
Novel Small Molecule Drugs, Targeting The Main Autophosphorylation Site (Y397) of Focal Adhesion Kinase, As an Effective Cancer Therapy Approach
#8,314,150
Issued March 2013
Kinase Protein Binding Inhibitors (CIP)
#8,404,669
Issued May 2013
Compounds and Methods for Treatment of Alpha-1 Antitrypsin Deficiency
#8,436,013
Issued June 2013
Method of Selectively Inhibiting PKCiota
#8,461,192
Issued July 2013
PDK Inhibitor Compounds and Methods of Use Thereof
#8,492,344
Issued August 2013
Methods and Compositions for Treating Neoplasia
#8,501,242
Issued October 2013
Novel Compounds that Suppress the Autophagic Response
#8,545,841
Issued October 2013
Cyclin Dependent Kinase Inhibitors
#8,569,356
Issued January 2014
Small Molecules that Target the Nuclear Export Signal of Topoisomerase II Alpha for the Treatment of Multiple Myeloma
#8,623,854
Issued August 2014
Therapeutic Combinations for Use in Neoplasia
#8,815,828
Issued September 2015
Compositions and Methods of Treating Neoplasia
#9,144,596
Issued April 2016
Method of Treating Ovarian Cancer Using a PKC Inhibitor
#9,301,965
Issued May 2016
ICA-1: A Novel PKC-Iota Inhibitor for the Treatment of Breast Cancer
#9,351,981
Issued December 2016
Therapeutic Combinations for Use in Neoplasia
#9,517,244
Issued April 2017
Topo II Inhibitor to Overcome De Novo Drug-Resistance in Multiple Myeloma
#9,616,051
Issued April 2017
Compounds that Modulate Autoimmunity and Methods of Using the Same
#9,629,848
Published July 2017
Method of Treating Colorectal Cancer
#US2018/0008564
Published September 2017
Long Acting Methyldopa for the Treatment of Type 1 Diabetes
#US2018/0116988

Contact Details

Phones:
Business:
(352) 273-8166